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Prof. Nicoletta BIGLIA

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Marchetti C, Ferrandina G, Cormio G, Gambino A, Cecere S, Lorusso D, De Giorgi U, Bogliolo S, Fagotti A, Mammoliti S, Narducci F, Bergamini A, Scollo P, Biglia N, Breda E, Tamberi S, Marinaccio M, Angioli R, Salerno L, Eusebi MC, Loizzi V, Scambia G, Panici PB. (2016) Brain metastases in patients with EOC: Clinico-pathological and prognostic factors. A multicentric retrospective analysis from the MITO group (MITO 19). Gynecologic oncology [DOI  PMID]

Fu Y, Biglia N, Wang Z, Shen Y, Risch HA, Lu L, Canuto EM, Jia W, Katsaros D, Yu H. (2016) Long non-coding RNAs, ASAP1-IT1, FAM215A, and LINC00472, in epithelial ovarian cancer. Gynecologic oncology [DOI  PMID]

Gennari A, Amadori D, Scarpi E, Farolfi A, Paradiso A, Mangia A, Biglia N, Gianni L, Tienghi A, Rocca A, Maltoni R, Antonucci G, Bruzzi P, Nanni O. (2016) Impact of body mass index (BMI) on the prognosis of high-risk early breast cancer (EBC) patients treated with adjuvant chemotherapy. Breast cancer research and treatment 159(1) 79-86 [DOI  PMID]

Nappi RE, Particco M, Biglia N, Cagnacci A, Di Carlo C, Luisi S, Paoletti AM. (2016) Attitudes and perceptions towards vulvar and vaginal atrophy in Italian post-menopausal women: Evidence from the European REVIVE survey. Maturitas 91 74-80 [DOI  PMID]

Gadducci A, Biglia N, Tana R, Cosio S, Gallo M. (2016) Metformin use and gynecological cancers: A novel treatment option emerging from drug repositioning. Critical reviews in oncology/hematology 105 73-83 [DOI  PMID]

Bounous VE, Ferrero A, Fuso L, Ravarino N, Ceccaroni M, Menato G, Biglia N. (2016) Endometriosis-associated Ovarian Cancer: A Distinct Clinical Entity? Anticancer research 36(7) 3445-9 [PMID]

Biglia N, Sgandurra P, Bounous VE, Maggiorotto F, Piva E, Pivetta E, Ponzone R, Pasini B. (2016) Ovarian cancer in BRCA1 and BRCA2 gene mutation carriers: analysis of prognostic factors and survival. Ecancermedicalscience 10 639 [DOI  PMID]

Zanfagnin V, Ferrero A, Biglia N, Aletti G, Gill SE, Makdisi PB, Multinu F, Mariani A. (2016) The role of surgery in recurrent endometrial cancer. Expert review of anticancer therapy 16(7) 741-50 [DOI  PMID]

Nappi RE, Biglia N, Cagnacci A, Di Carlo C, Luisi S, Paoletti AM. (2016) Diagnosis and management of symptoms associated with vulvovaginal atrophy: expert opinion on behalf of the Italian VVA study group . Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 1-5 [DOI  PMID]

Biglia N, Bounous VE, Susini T, Pecchio S, Sgro LG, Tuninetti V, Torta R. (2016) Duloxetine and escitalopram for hot flushes: efficacy and compliance in breast cancer survivors. European journal of cancer care [DOI  PMID]

Biglia N, D'Alonzo M, Sgro LG, Tomasi Cont N, Bounous V, Robba E. (2016) Breast cancer treatment in mutation carriers: surgical treatment. Minerva ginecologica 68(5) 548-56 [PMID]

Lu L, Katsaros D, Canuto EM, Biglia N, Risch HA, Yu H. (2016) LIN-28B/let-7a/IGF-II axis molecular subtypes are associated with epithelial ovarian cancer prognosis. Gynecologic oncology 141(1) 121-7 [DOI  PMID]

Cont NT, Ferrero A, Peccatori FA, D'Alonzo M, Codacci-Pisanelli G, Colombo N, Biglia N. (2015) Medical treatment of early stage and rare histological variants of epithelial ovarian cancer. Ecancermedicalscience 9 584 [DOI  PMID]

Biglia N, Bounous VE, Sgro LG, D'Alonzo M, Gallo M. (2015) Treatment of climacteric symptoms in survivors of gynaecological cancer. Maturitas 82(3) 296-8 [DOI  PMID]

Sismondi P, D'Alonzo M, Pecchio S, Bounous VE, Robba E, Biglia N. (2015) Chemoprevention or mastectomy for women at high risk of developing breast cancer. Maturitas 82(3) 271-3 [DOI  PMID]

Farolfi A, Scarpi E, Rocca A, Mangia A, Biglia N, Gianni L, Tienghi A, Valerio MR, Gasparini G, Amaducci L, Faedi M, Baldini E, Rubagotti A, Maltoni R, Paradiso A, Amadori D. (2015) Time to initiation of adjuvant chemotherapy in patients with rapidly proliferating early breast cancer. European journal of cancer (Oxford, England : 1990) 51(14) 1874-81 [DOI  PMID]

Biglia N, Bounous VE, Sgro LG, D'Alonzo M, Pecchio S, Nappi RE. (2015) Genitourinary Syndrome of Menopause in Breast Cancer Survivors: Are We Facing New and Safe Hopes? Clinical breast cancer 15(6) 413-20 [DOI  PMID]

Castelo-Branco C, Biglia N, Nappi RE, Schwenkhagen A, Palacios S. (2015) Characteristics of post-menopausal women with genitourinary syndrome of menopause: Implications for vulvovaginal atrophy diagnosis and treatment selection. Maturitas 81(4) 462-9 [DOI  PMID]

Despierre E, Vergote I, Anderson R, Coens C, Katsaros D, Hirsch FR, Boeckx B, Varella-Garcia M, Ferrero A, Ray-Coquard I, Berns EM, Casado A, Lambrechts D, Jimeno A. (2015) Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy. Targeted oncology 10(4) 583-96 [DOI  PMID]

Biglia N, Torrisi R, D'Alonzo M, Codacci Pisanelli G, Rota S, Peccatori FA. (2015) Attitudes on fertility issues in breast cancer patients: an Italian survey. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 31(6) 458-64 [DOI  PMID]

Su D, Katsaros D, Xu S, Xu H, Gao Y, Biglia N, Feng J, Ying L, Zhang P, Benedetto C, Yu H. (2015) ADP-ribosylation factor-like 4C (ARL4C), a novel ovarian cancer metastasis suppressor, identified by integrated genomics. American journal of translational research 7(2) 242-56 [PMID]

Shen Y, Katsaros D, Loo LW, Hernandez BY, Chong C, Canuto EM, Biglia N, Lu L, Risch H, Chu WM, Yu H. (2015) Prognostic and predictive values of long non-coding RNA LINC00472 in breast cancer. Oncotarget 6(11) 8579-92 [DOI  PMID]

Daniele A, Ferrero A, Fuso L, Mineccia M, Porcellana V, Vassallo D, Biglia N, Menato G. (2015) Palliative care in patients with ovarian cancer and bowel obstruction. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 23(11) 3157-63 [DOI  PMID]

Lu L, Katsaros D, Risch HA, Canuto EM, Biglia N, Yu H. (2016) MicroRNA let-7a modifies the effect of self-renewal gene HIWI on patient survival of epithelial ovarian cancer. Molecular carcinogenesis 55(4) 357-65 [DOI  PMID]

Biglia N, Librino A, Ottino MC, Panuccio E, Daniele A, Chahin A. (2015) Lower limb lymphedema and neurological complications after lymphadenectomy for gynecological cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 25(3) 521-5 [DOI  PMID]

Biglia N, Ponzone R, Bounous VE, Mariani LL, Maggiorotto F, Benevelli C, Liberale V, Ottino MC, Sismondi P. (2014) Role of re-excision for positive and close resection margins in patients treated with breast-conserving surgery. Breast (Edinburgh, Scotland) 23(6) 870-5 [DOI  PMID]

Greggi S, Franchi M, Aletti G, Biglia N, Ditto A, Fagotti A, Giorda G, Mangili G, Odicino F, Salerno MG, Vizza E, Scaffa C, Scollo P. (2014) Management of endometrial cancer in Italy: a national survey endorsed by the Italian Society of Gynecologic Oncology. International journal of surgery (London, England) 12(10) 1038-44 [DOI  PMID]

Mancari R, Tomasi-Cont N, Sarno MA, Azim HA Jr, Franchi D, Carinelli S, Biglia N, Colombo N, Peccatori FA. (2014) Treatment options for pregnant women with ovarian tumors. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 24(6) 967-72 [DOI  PMID]

Natoli C, Brocco D, Sperduti I, Nuzzo A, Tinari N, De Tursi M, Grassadonia A, Mazzilli L, Iacobelli S, Gamucci T, Vici P. (2014) Breast cancer "tailored follow-up" in Italian oncology units: a web-based survey. PloS one 9(4) e94063 [DOI  PMID]

Biglia N, Carinelli S, Maiorana A, D'Alonzo M, Lo Monte G, Marci R. (2014) Ulipristal acetate: a novel pharmacological approach for the treatment of uterine fibroids. Drug design, development and therapy 8 285-92 [DOI  PMID]

Rocca A, Bravaccini S, Scarpi E, Mangia A, Petroni S, Puccetti M, Medri L, Serra L, Ricci M, Cerasoli S, Biglia N, Maltoni R, Giunchi DC, Gianni L, Tienghi A, Brandi M, Faedi M, Sismondi P, Paradiso A, Silvestrini R, Amadori D. (2014) Benefit from anthracyclines in relation to biological profiles in early breast cancer. Breast cancer research and treatment 144(2) 307-18 [DOI  PMID]

Ferrero A, Ditto A, Giorda G, Gadducci A, Greggi S, Daniele A, Fuso L, Panuccio E, Scaffa C, Raspagliesi F, Sismondi P, Biglia N. (2014) Secondary cytoreductive surgery for isolated lymph node recurrence of epithelial ovarian cancer: a multicenter study. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 40(7) 891-8 [DOI  PMID]

Campagnoli C, Berrino F, Venturelli E, Abba C, Biglia N, Brucato T, Cogliati P, Danese S, Donadio M, Zito G, Pasanisi P. (2013) Metformin decreases circulating androgen and estrogen levels in nondiabetic women with breast cancer. Clinical breast cancer 13(6) 433-8 [DOI  PMID]

DeCensi A, Bonanni B, Maisonneuve P, Serrano D, Omodei U, Varricchio C, Cazzaniga M, Lazzeroni M, Rotmensz N, Santillo B, Sideri M, Cassano E, Belloni C, Muraca M, Segnan N, Masullo P, Costa A, Monti N, Vella A, Bisanti L, D'Aiuto G, Veronesi U. (2013) A phase-III prevention trial of low-dose tamoxifen in postmenopausal hormone replacement therapy users: the HOT study. Annals of oncology : official journal of the European Society for Medical Oncology 24(11) 2753-60 [DOI  PMID]

Lu L, Risch E, Deng Q, Biglia N, Picardo E, Katsaros D, Yu H. (2013) An insulin-like growth factor-II intronic variant affects local DNA conformation and ovarian cancer survival. Carcinogenesis 34(9) 2024-30 [DOI  PMID]

Biglia N, Maggiorotto F, Liberale V, Bounous VE, Sgro LG, Pecchio S, D'Alonzo M, Ponzone R. (2013) Clinical-pathologic features, long term-outcome and surgical treatment in a large series of patients with invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC). European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 39(5) 455-60 [DOI  PMID]

Cimino D, De Pitta C, Orso F, Zampini M, Casara S, Penna E, Quaglino E, Forni M, Damasco C, Pinatel E, Ponzone R, Romualdi C, Brisken C, De Bortoli M, Biglia N, Provero P, Lanfranchi G, Taverna D. (2013) miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 27(3) 1223-35 [DOI  PMID]

Biglia N, Peano E, Sgandurra P, Moggio G, Pecchio S, Maggiorotto F, Sismondi P. (2013) Body mass index (BMI) and breast cancer: impact on tumor histopathologic features, cancer subtypes and recurrence rate in pre and postmenopausal women. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 29(3) 263-7 [DOI  PMID]

Recupero D, Daniele L, Marchio C, Molinaro L, Castellano I, Cassoni P, Righi A, Montemurro F, Sismondi P, Biglia N, Viale G, Risio M, Sapino A. (2013) Spontaneous and pronase-induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines. The Journal of pathology 229(3) 390-9 [DOI  PMID]

Ferrero A, Strada I, Di Marcoberardino B, Maccarini LR, Pozzati F, Rossi M, Biglia N, De Iaco P. (2012) Clinical significance of microinvasion in borderline ovarian tumors and its impact on surgical management. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 22(7) 1158-62 [DOI  PMID]

D'Alonzo M, Martincich L, Biglia N, Pisacane A, Maggiorotto F, Rosa GD, Montemurro F, Kubatzki F, Sismondi P, Ponzone R. (2012) Clinical and radiological predictors of nipple-areola complex involvement in breast cancer patients. European journal of cancer (Oxford, England : 1990) 48(15) 2311-8 [DOI  PMID]

Campagnoli C, Pasanisi P, Abba C, Ambroggio S, Biglia N, Brucato T, Colombero R, Danese S, Donadio M, Venturelli E, Zito G, Berrino F. (2012) Effect of different doses of metformin on serum testosterone and insulin in non-diabetic women with breast cancer: a randomized study. Clinical breast cancer 12(3) 175-82 [DOI  PMID]

Lorenzato A, Martino C, Dani N, Oligschlager Y, Ferrero AM, Biglia N, Calogero R, Olivero M, Di Renzo MF. (2012) The cellular apoptosis susceptibility CAS/CSE1L gene protects ovarian cancer cells from death by suppressing RASSF1C. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26(6) 2446-56 [DOI  PMID]

Ferraro L, Ravo M, Nassa G, Tarallo R, De Filippo MR, Giurato G, Cirillo F, Stellato C, Silvestro S, Cantarella C, Rizzo F, Cimino D, Friard O, Biglia N, De Bortoli M, Cicatiello L, Nola E, Weisz A. (2012) Effects of oestrogen on microRNA expression in hormone-responsive breast cancer cells. Hormones & cancer 3(3) 65-78 [DOI  PMID]

Biglia N, Bounous VE, Malabaila A, Palmisano D, Torta DM, D'Alonzo M, Sismondi P, Torta R. (2012) Objective and self-reported cognitive dysfunction in breast cancer women treated with chemotherapy: a prospective study. European journal of cancer care 21(4) 485-92 [DOI  PMID]

Sismondi P, Kimmig R, Kubista E, Biglia N, Egberts J, Mulder R, Planellas J, Moggio G, Mol-Arts M, Kenemans P. (2011) Effects of tibolone on climacteric symptoms and quality of life in breast cancer patients--data from LIBERATE trial. Maturitas 70(4) 365-72 [DOI  PMID]

Biglia N, Bounous VE, Martincich L, Panuccio E, Liberale V, Ottino L, Ponzone R, Sismondi P. (2011) Role of MRI (magnetic resonance imaging) versus conventional imaging for breast cancer presurgical staging in young women or with dense breast. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 37(3) 199-204 [DOI  PMID]

Amadori D, Silvestrini R, De Lena M, Boccardo F, Rocca A, Scarpi E, Schittulli F, Brandi M, Maltoni R, Serra P, Ponzone R, Biglia N, Gianni L, Tienghi A, Valerio MR, Bonginelli P, Amaducci L, Faedi M, Baldini E, Paradiso A. (2011) Randomized phase III trial of adjuvant epirubicin followed by cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) versus CMF followed by epirubicin in patients with node-negative or 1-3 node-positive rapidly proliferating breast cancer. Breast cancer research and treatment 125(3) 775-84 [DOI  PMID]

Gadducci A, Biglia N, Cosio S, Sismondi P, Genazzani AR. (2010) Gynaecologic challenging issues in the management of BRCA mutation carriers: oral contraceptives, prophylactic salpingo-oophorectomy and hormone replacement therapy. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 26(8) 568-77 [DOI  PMID]

Biglia N, Maffei S, Lello S, Nappi RE. (2010) Tibolone in postmenopausal women: a review based on recent randomised controlled clinical trials. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 26(11) 804-14 [DOI  PMID]

Biglia N, Moggio G, Peano E, Sgandurra P, Ponzone R, Nappi RE, Sismondi P. (2010) Effects of surgical and adjuvant therapies for breast cancer on sexuality, cognitive functions, and body weight. The journal of sexual medicine 7(5) 1891-900 [DOI  PMID]

Biglia N, Peano E, Sgandurra P, Moggio G, Panuccio E, Migliardi M, Ravarino N, Ponzone R, Sismondi P. (2010) Low-dose vaginal estrogens or vaginal moisturizer in breast cancer survivors with urogenital atrophy: a preliminary study. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 26(6) 404-12 [DOI  PMID]

Gadducci A, Biglia N, Cosio S, Sismondi P, Genazzani AR. (2009) Progestagen component in combined hormone replacement therapy in postmenopausal women and breast cancer risk: a debated clinical issue. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 25(12) 807-15 [DOI  PMID]

Ponzone R, Cont NT, Maggiorotto F, Cassina E, Mininanni P, Biglia N, Sismondi P. (2009) Extensive nodal disease may impair axillary reverse mapping in patients with breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27(33) 5547-51 [DOI  PMID]

Biglia N, Sgandurra P, Peano E, Marenco D, Moggio G, Bounous V, Tomasi Cont N, Ponzone R, Sismondi P. (2009) Non-hormonal treatment of hot flushes in breast cancer survivors: gabapentin vs. vitamin E. Climacteric : the journal of the International Menopause Society 12(4) 310-8 [DOI  PMID]

Kenemans P, Bundred NJ, Foidart JM, Kubista E, von Schoultz B, Sismondi P, Vassilopoulou-Sellin R, Yip CH, Egberts J, Mol-Arts M, Mulder R, van Os S, Beckmann MW. (2009) Safety and efficacy of tibolone in breast-cancer patients with vasomotor symptoms: a double-blind, randomised, non-inferiority trial. The Lancet. Oncology 10(2) 135-46 [DOI  PMID]

De Iaco P, Ferrero A, Rosati F, Melpignano M, Biglia N, Rolla M, De Aloysio D, Sismondi P. (2009) Behaviour of ovarian tumors of low malignant potential treated with conservative surgery. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 35(6) 643-8 [DOI  PMID]

Ponzone R, Cassina E, Tomasi Cont N, Biglia N, Sismondi P. (2009) Decreasing arm morbidity by refining axillary surgery in breast cancer. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 35(4) 335-8 [DOI  PMID]

Cimino D, Fuso L, Sfiligoi C, Biglia N, Ponzone R, Maggiorotto F, Russo G, Cicatiello L, Weisz A, Taverna D, Sismondi P, De Bortoli M. (2008) Identification of new genes associated with breast cancer progression by gene expression analysis of predefined sets of neoplastic tissues. International journal of cancer 123(6) 1327-38 [DOI  PMID]

Giretti MS, Fu XD, De Rosa G, Sarotto I, Baldacci C, Garibaldi S, Mannella P, Biglia N, Sismondi P, Genazzani AR, Simoncini T. (2008) Extra-nuclear signalling of estrogen receptor to breast cancer cytoskeletal remodelling, migration and invasion. PloS one 3(5) e2238 [DOI  PMID]

Biglia N, Mariani L, Ponzone R, Sismondi P. (2008) Oral contraceptives, salpingo-oophorectomy and hormone replacement therapy in BRCA1-2 mutation carriers. Maturitas 60(2) 71-7 [DOI  PMID]

Ponzone R, Biglia N, Roagna R, Sgro L, Sismondi P. (2008) The Academic Division of Breast and Gynaecological Oncology of the Institute for Cancer Research and Treatment (IRCC) of Candiolo, Turin, Italy. Breast care (Basel, Switzerland) 3(4) 287-288 [DOI  PMID]

Genazzani A, Gambacciani M, Simoncini T, Anniverno R, Becorpi AM, Biglia N, Brandi ML, Guaschino S, Lello S, Massobrio M, Melis GB, Mencacci C, Modena MG, Nappi C, Nappi RE, Pecorelli S, Petraglia F, Rosano GM, Serra GB, Sismondi P, Taddei S, Tonelli F. (2007) Italian position statement on hormone replacement therapy following the National Conference on Menopause and Hormone Replacement Therapy, Villa Tuscolana, Frascati (Rome), May 8-9, 2007. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 23(8) 436-44 [DOI  PMID]

Biglia N, Mariani L, Sgro L, Mininanni P, Moggio G, Sismondi P. (2007) Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: implications for diagnosis, surgical and medical treatment. Endocrine-related cancer 14(3) 549-67 [DOI  PMID]

Biglia N, Kubatzki F, Sgandurra P, Ponzone R, Marenco D, Peano E, Sismondi P. (2007) Mirtazapine for the treatment of hot flushes in breast cancer survivors: a prospective pilot trial. The breast journal 13(5) 490-5 [DOI  PMID]

Ponzone R, Maggiorotto F, Mariani L, Jacomuzzi ME, Magistris A, Mininanni P, Biglia N, Sismondi P. (2007) Comparison of two models for the prediction of nonsentinel node metastases in breast cancer. American journal of surgery 193(6) 686-92 [DOI  PMID]

Ponzone R, Dominguez A, Marra V, Pisacane A, Maggiorotto F, Jacomuzzi ME, Magistris A, Biglia N, Sismondi P. (2007) Pathological classification of ductal carcinoma in situ of the breast correlates with surgical treatment and may be predicted by mammography. Breast (Edinburgh, Scotland) 16(5) 495-502 [DOI  PMID]

Sismondi P, Biglia N, Ponzone R, Fuso L, Scafoglio C, Cicatiello L, Ravo M, Weisz A, Cimino D, Altobelli G, Friard O, De Bortoli M. (2007) Influence of estrogens and antiestrogens on the expression of selected hormone-responsive genes. Maturitas 57(1) 50-5 [DOI  PMID]

Ponzone R, Biglia N, Jacomuzzi ME, Mariani L, Dominguez A, Sismondi P. (2006) Antihormones in prevention and treatment of breast cancer. Annals of the New York Academy of Sciences 1089 143-58 [DOI  PMID]

Biglia N, Mariani L, Marenco D, Robba C, Peano E, Kubatzki F, Sismondi P. (2006) Hormonal replacement therapy after gynaecological cancer. Gynakologisch-geburtshilfliche Rundschau 46(4) 191-6 [DOI  PMID]

Ponzone R, Montemurro F, Maggiorotto F, Robba C, Gregori D, Jacomuzzi ME, Kubatzki F, Marenco D, Dominguez A, Biglia N, Sismondi P. (2006) Clinical outcome of adjuvant endocrine treatment according to PR and HER-2 status in early breast cancer. Annals of oncology : official journal of the European Society for Medical Oncology 17(11) 1631-6 [DOI  PMID]

Scafoglio C, Ambrosino C, Cicatiello L, Altucci L, Ardovino M, Bontempo P, Medici N, Molinari AM, Nebbioso A, Facchiano A, Calogero RA, Elkon R, Menini N, Ponzone R, Biglia N, Sismondi P, De Bortoli M, Weisz A. (2006) Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. Journal of cellular biochemistry 98(5) 1163-84 [DOI  PMID]

Biglia N, Ujcic E, Kubatzki F, Sgandurra P, Robba C, Ponzone R, Sismondi P. (2006) Personal use of hormone therapy by postmenopausal women doctors and male doctors' wives in Italy after the publication of WHI trial. Maturitas 54(2) 181-92 [DOI  PMID]

Ponzone R, Biglia N, Jacomuzzi ME, Maggiorotto F, Mariani L, Sismondi P. (2005) Vaginal oestrogen therapy after breast cancer: is it safe? European journal of cancer (Oxford, England : 1990) 41(17) 2673-81 [DOI  PMID]

Biglia N, Torta R, Roagna R, Maggiorotto F, Cacciari F, Ponzone R, Kubatzki F, Sismondi P. (2005) Evaluation of low-dose venlafaxine hydrochloride for the therapy of hot flushes in breast cancer survivors. Maturitas 52(1) 78-85 [DOI  PMID]

Gadducci A, Biglia N, Sismondi P, Genazzani AR. (2005) Breast cancer and sex steroids: critical review of epidemiological, experimental and clinical investigations on etiopathogenesis, chemoprevention and endocrine treatment of breast cancer. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20(6) 343-60 [DOI  PMID]

Biglia N, Sgro L, Defabiani E, De Rosa G, Ponzone R, Marenco D, Sismondi P. (2005) The influence of hormone replacement therapy on the pathology of breast cancer. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 31(5) 467-72 [DOI  PMID]

Montemurro F, Martincich L, De Rosa G, Cirillo S, Marra V, Biglia N, Gatti M, Sismondi P, Aglietta M, Regge D. (2005) Dynamic contrast-enhanced MRI and sonography in patients receiving primary chemotherapy for breast cancer. European radiology 15(6) 1224-33 [DOI  PMID]

Biglia N, Gadducci A, Ponzone R, Roagna R, Sismondi P. (2004) Hormone replacement therapy in cancer survivors. Maturitas 48(4) 333-46 [DOI  PMID]

Biglia N, Cozzarella M, Ponzone R, Marenco D, Maggiorotto F, Fuso L, Sismondi P. (2004) Personal use of HRT by postmenopausal women doctors and doctors' wives in the north of Italy. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 18(3) 165-74 [PMID]

Sismondi P, Biglia N. (2004) HRT and gynaecologic cancer after WHI: old stuff or new doubts? Maturitas 48(1) 13-8 [DOI  PMID]

Ponzone R, Biglia N, Sismondi P. (2004) Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. Journal of the National Cancer Institute 96(11) 883-4; author reply 884-5 [PMID]

Cicatiello L, Scafoglio C, Altucci L, Cancemi M, Natoli G, Facchiano A, Iazzetti G, Calogero R, Biglia N, De Bortoli M, Sfiligoi C, Sismondi P, Bresciani F, Weisz A. (2004) A genomic view of estrogen actions in human breast cancer cells by expression profiling of the hormone-responsive transcriptome. Journal of molecular endocrinology 32(3) 719-75 [PMID]

Biglia N, Defabiani E, Ponzone R, Mariani L, Marenco D, Sismondi P. (2004) Management of risk of breast carcinoma in postmenopausal women. Endocrine-related cancer 11(1) 69-83 [PMID]

Martincich L, Montemurro F, De Rosa G, Marra V, Ponzone R, Cirillo S, Gatti M, Biglia N, Sarotto I, Sismondi P, Regge D, Aglietta M. (2004) Monitoring response to primary chemotherapy in breast cancer using dynamic contrast-enhanced magnetic resonance imaging. Breast cancer research and treatment 83(1) 67-76 [DOI  PMID]

Ponzone R, Biglia N, Maggiorotto F, Kubatzki F, Elia O, De Rosa G, Sismondi P. (2003) Sentinel node dissection as definitive treatment for node negative breast cancer patients. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 29(9) 703-6 [PMID]

Biglia N, Ambroggio S, Ponzone R, Sgro L, Ujcic E, Dato FA, Sismondi P. (2003) Modification of serum IGF-I, IGFBPs and SHBG levels by different HRT regimens. Maturitas 45(4) 283-91 [PMID]

Sorbello V, Fuso L, Sfiligoi C, Scafoglio C, Ponzone R, Biglia N, Weisz A, Sismondi P, De Bortoli M. (2003) Quantitative real-time RT-PCR analysis of eight novel estrogen-regulated genes in breast cancer. The International journal of biological markers 18(2) 123-9 [PMID]

Biglia N, Cozzarella M, Cacciari F, Ponzone R, Roagna R, Maggiorotto F, Sismondi P. (2003) Menopause after breast cancer: a survey on breast cancer survivors. Maturitas 45(1) 29-38 [PMID]

Yousef GM, Scorilas A, Nakamura T, Ellatif MA, Ponzone R, Biglia N, Maggiorotto F, Roagna R, Sismondi P, Diamandis EP. (2003) The prognostic value of the human kallikrein gene 9 (KLK9) in breast cancer. Breast cancer research and treatment 78(2) 149-58 [PMID]

Sismondi P, Ponzone R, Biglia N, Roagna R, Cacciari F, Maggiorotto F. (2003) Sentinel node biopsy for breast cancer: yes, less surgery is better surgery. European journal of gynaecological oncology 24(2) 107-12 [PMID]

Biglia N, De Bortoli M. (2003) Molecular characterization of breast cancer aggressiveness. The International journal of biological markers 18(1) 36-9 [PMID]

Sfiligoi C, de Luca A, Cascone I, Sorbello V, Fuso L, Ponzone R, Biglia N, Audero E, Arisio R, Bussolino F, Sismondi P, De Bortoli M. (2003) Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival. International journal of cancer 103(4) 466-74 [DOI  PMID]

Yousef GM, Scorilas A, Magklara A, Memari N, Ponzone R, Sismondi P, Biglia N, Abd Ellatif M, Diamandis EP. (2002) The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer. British journal of cancer 87(11) 1294-300 [DOI  PMID]

Yousef GM, Borgono CA, Scorilas A, Ponzone R, Biglia N, Iskander L, Polymeris ME, Roagna R, Sismondi P, Diamandis EP. (2002) Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis. British journal of cancer 87(11) 1287-93 [DOI  PMID]

Campagnoli C, Abba C, Ambroggio S, Biglia N, Ponzone R. (2001) Breast cancer and hormone replacement therapy: putting the risk into perspective. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 15 Suppl 6 53-60 [PMID]

Yousef GM, Scorilas A, Kyriakopoulou LG, Rendl L, Diamandis M, Ponzone R, Biglia N, Giai M, Roagna R, Sismondi P, Diamandis EP. (2002) Human kallikrein gene 5 (KLK5) expression by quantitative PCR: an independent indicator of poor prognosis in breast cancer. Clinical chemistry 48(8) 1241-50 [PMID]

Bertelli G, Venturini M, Del Mastro L, Bergaglio M, Sismondi P, Biglia N, Venturini S, Porcile G, Pronzato P, Costantini M, Rosso R. (2002) Intramuscular depot medroxyprogesterone versus oral megestrol for the control of postmenopausal hot flashes in breast cancer patients: a randomized study. Annals of oncology : official journal of the European Society for Medical Oncology 13(6) 883-8 [PMID]

Sismondi P, Biglia N, Ujcic E, Ponzone R, Roagna R. (2001) Raloxifene and endometrial cancer. Tumori 87(5) S18-9 [PMID]

Cottone E, Orso F, Biglia N, Sismondi P, De Bortoli M. (2001) Role of coactivators and corepressors in steroid and nuclear receptor signaling: potential markers of tumor growth and drug sensitivity. The International journal of biological markers 16(3) 151-66 [PMID]

Sismondi P, Biglia N, Roagna R, Ponzone R, Ambroggio S, Sgro L, Cozzarella M. (2000) How to manage the menopause following therapy for breast cancer. is raloxifene a safe alternative? European journal of cancer (Oxford, England : 1990) 36 Suppl 4 S74-6 [PMID]

Campagnoli C, Ambroggio S, Biglia N, Sismondi P. (1999) Conjugated estrogens and breast cancer risk. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 13 Suppl 6 13-9 [PMID]

De Benedetti VM, Biglia N, Sismondi P, De Bortoli M. (2000) DNA chips: the future of biomarkers. The International journal of biological markers 15(1) 1-9 [PMID]

Campagnoli C, Biglia N, Cantamessa C, Lesca L, Sismondi P. (1999) HRT and breast cancer risk: a clue for interpreting the available data. Maturitas 33(3) 185-90 [PMID]

Sismondi P, Biglia N, Giai M, Ponzone R, Roagna R, Sgro L, Campagnoli C. (1999) HRT, breast and endometrial cancers: strategies and intervention options. Maturitas 32(3) 131-9 [PMID]

Becchis M, Frairia R, Ferrera P, Fazzari A, Ondei S, Alfarano A, Coluccia C, Biglia N, Sismondi P, Fortunati N. (1999) The additionally glycosylated variant of human sex hormone-binding globulin (SHBG) is linked to estrogen-dependence of breast cancer. Breast cancer research and treatment 54(2) 101-7 [PMID]

Campagnoli C, Biglia N, Cantamessa C, Lesca L, Lotano MR, Sismondi P. (1998) Insulin-like growth factor I (IGF-I) serum level modifications during transdermal estradiol treatment in postmenopausal women: a possible bimodal effect depending on basal IGF-I values. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 12(4) 259-66 [PMID]

Campagnoli C, Ambroggio S, Biglia N, Peris C, Sismondi P. (1998) Insulin-like growth factor-I and risk of breast cancer. Lancet (London, England) 352(9126) 488-9 [PMID]

Ponzone R, Giai M, Roagna R, Sgro L, Biglia N, Welch H, Sismondi P. (1997) Clinical and ethical issues in the diagnosis of hereditary breast cancer (review). International journal of oncology 10(2) 323-8 [PMID]

Campagnoli C, Biglia N, Giai M, Sismondi P. (1997) Progestins and breast cancer risk. Zentralblatt fur Gynakologie 119 Suppl 2 38-42 [PMID]

Campagnoli C, Biglia N, Cantamessa C, Di Sario MM, Lesca L. (1997) Effect of progestins on IGF-I serum level in estrogen-treated postmenopausal women. Zentralblatt fur Gynakologie 119 Suppl 2 7-11 [PMID]

Campagnoli C, Cantamessa C, Lesca L, Sismondi P, Biglia N. (1996) Misplaced confidences? Fertility and sterility 66(5) 859-61 [PMID]

Traina A, Cusimano R, Liquori M, Calabria C, Biglia N, Ponzone R, Sgro L, Sismondi P. (1996) Oral contraceptive use and breast cancer risk in areas with different incidence. A case-control study among young women. Annals of the New York Academy of Sciences 784 564-9 [PMID]

Campagnoli C, Biglia N, Sismondi P. (1996) Hormone replacement therapy and breast cancer risk. JAMA 275(15) 1159-60 [PMID]

Giai M, Roagna R, Ponzone R, Biglia N, Sgro L, Perona M, Sismondi P. (1996) TPS and CA 15.3 serum values as a guide for treating and monitoring breast cancer patients. Anticancer research 16(2) 875-81 [PMID]

Sismondi P, Biglia N. (1995) Critical review of the article by Colditz et al. on 'The use of estrogens and progestins and the risk of breast cancer in postmenopausal women' published in the N.E.J.M. 1995, 332: 1589. Pharmacological research 32(6) 329-30 [PMID]

Campagnoli C, Biglia N, Peris C, Sismondi P. (1995) Potential impact on breast cancer risk of circulating insulin-like growth factor I modifications induced by oral HRT in menopause. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 9(1) 67-74 [PMID]

Sismondi P, Biglia N, Volpi E, Giai M, de Grandis T. (1994) Tamoxifen and endometrial cancer. Annals of the New York Academy of Sciences 734 310-21 [PMID]

Sismondi P, Biglia N, Giai M, Sgro L, Campagnoli C. (1994) Metabolic effects of tamoxifen in postmenopause. Anticancer research 14(5B) 2237-44 [PMID]

Campagnoli C, Biglia N, Lanza MG, Lesca L, Peris C, Sismondi P. (1994) Androgenic progestogens oppose the decrease of insulin-like growth factor I serum level induced by conjugated oestrogens in postmenopausal women. Preliminary report. Maturitas 19(1) 25-31 [PMID]

Sismondi P, Biglia N, Giai M, Defabiani E. (1994) GnRH analogs in benign breast disease and breast cancer chemoprevention. A challenge for the year 2000. European journal of gynaecological oncology 15(2) 108-14 [PMID]

Campagnoli C, Biglia N, Altare F, Lanza MG, Lesca L, Cantamessa C, Peris C, Fiorucci GC, Sismondi P. (1993) Differential effects of oral conjugated estrogens and transdermal estradiol on insulin-like growth factor 1, growth hormone and sex hormone binding globulin serum levels. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 7(4) 251-8 [PMID]

Campagnoli C, Lanza MG, Peris C, Biglia N, Sismondi P. (1992) Oral contraceptives and breast cancer. Fertility and sterility 58(6) 1270-1; author reply 1272 [PMID]

Campagnoli C, Biglia N, Belforte P, Botta D, Pedrini E, Sismondi P. (1992) Post-menopausal breast cancer risk: oral estrogen treatment and abdominal obesity induce opposite changes in possibly important biological variables. European journal of gynaecological oncology 13(2) 139-54 [PMID]

Biglia N, Giai M, Cortese P, Bottero A, Sismondi P. (1991) [Postoperative infections and antibiotic prophylaxis in radical hysterectomy. Retrospective study]. Minerva ginecologica 43(10) 435-41 [PMID]

Biglia N, Giai M, Sismondi P. (1991) [Postoperative infections and antibiotic prophylaxis in radical hysterectomy. Review of the literature]. Minerva ginecologica 43(10) 425-33 [PMID]

Giai M, Biglia N, Sismondi P. (1991) Chemoresistance in breast tumors. European journal of gynaecological oncology 12(5) 359-73 [PMID]

Giai M, Natoli C, Sismondi P, Biglia N, Lesti G, Mulieri M, Iacobelli S. (1990) Bone marrow micrometastases detected by a monoclonal antibody in patients with breast cancer. Anticancer research 10(1) 119-21 [PMID]

Sismondi P, Giai M, Defabiani E, Biglia N. (1990) Benign breast disease. An update. Clinical and experimental obstetrics & gynecology 17(2) 53-116 [PMID]

Grio R, Zaccheo F, Mazza O, Giacardi M, Tumiati L, Biglia N, Malara D, Giobbe C, Cellura A. (1988) [Obstetric future of women having undergone cesarean section]. Minerva ginecologica 40(11) 657-60 [PMID]

Saglio G, Camaschella C, Giai M, Serra A, Guerrasio A, Peirone B, Gasparini P, Mazza U, Ceppellini R, Biglia N, et al.. (1988) Distribution of Ha-RAS-1 proto-oncogene alleles in breast cancer patients and in a control population. Breast cancer research and treatment 11(2) 147-53 [PMID]

Sorisio V, Amerio GM, Stillo R, Biglia N. (1987) [Cancer of the male breast. Presentation of 4 cases]. Minerva chirurgica 42(17) 1315-7 [PMID]

Corsi di insegnamento

Ricevimento studenti

Previo appuntamento telefonico 011-5082860
o via e-mail nicoletta.biglia@unito.it

Temi di ricerca

Nicoletta Biglia è PA di Ginecologia e Ostetricia con particolari competenze nel campo dell’oncologia ginecologica e
mammaria.
Nello sviluppo del suo curriculum formativo e professionale si è dedicata alla didattica, alla ricerca, e, in campo clinico,
soprattutto all’aspetto chirurgico della ginecologia.
Sin dai primi tempi dopo la Laurea, durante la Scuola di Specialità, il Dottorato di Ricerca in Scienze Oncologiche in Ginecologia
e per tutti gli anni successivi ha lavorato all’interno di un team dedicato all’oncologia ginecologica e mammaria acquisendo una
profonda conoscenza della storia naturale della malattia, una ottima capacità di interazione con gli altri attori (anatomopatologo,
radiologo, radioterapista, oncologo medico, ecc) e una piena autonomia nella chirurgia radicale della pelvi e della mammella.
Inoltre la quotidiana collaborazione di oltre 15 anni con i chirurghi generali per la chirurgia intestinale e dell’alto addome,
soprattutto nei tumori dell’ovaio, le ha permesso di sviluppare capacità tecniche che vanno oltre la chirurgia della pelvi e dei
linfonodi regionali, come ormai si richiede ad un Ginecologo Oncologo.
Ha sviluppato e sta ulteriormente perfezionando le sue conoscenze e competenze nella chirurgia mini invasiva e robotica con
corsi di perfezionamento e stages in Centri di eccellenza in Italia, Francia e USA.
Ha sempre dedicato grande attenzione a tutti gli aspetti legati alla qualità di vita delle pazienti oncologiche. Una particolare
sensibilità alla necessità di armonizzare radicalità e qualità di vita l’ha portata a dedicarsi e ad implementare tecniche chirurgiche
sempre più rispettose dell’integrità fisica delle pazienti (chirurgia oncoplastica e ricostruttiva della mammella, chirurgia nerve
sparing e approccio mini invasivo nella pelvi).
La preservazione della fertilità e la gravidanza nelle pazienti oncologiche, insieme con la gestione dei sintomi menopausali nelle
pazienti con tumori ormonoresponsivi, sono altri importanti argomenti ai quali si è dedicata, sia sul piano clinico sia su quello
della ricerca, e nei quali la sua esperienza è riconosciuta a livello internazionale.
La qualità della produzione scientifica è dimostrata dalla abilitazione scientifica nazionale per PO ottenuta nella prima tornata.
La propensione alla didattica è sottolineata anche dall’ideazione e dall’organizzazione del Master “Breast Nurse” che si aggiunge
alle normali attività nell’ambito della Scuola di Medicina, di Specializzazione, di Dottorato di Rierca e nei corsi di Laurea
Specialistica.
E' responsabile della Breast Unit presso la SCdU di Ginecologie e Ostetricia dell'Ospedale Mauriziano Umberto I di Torino
La capacità organizzativa è stata sviluppata in anni di responsabilità della gestione di attività multidisciplinari e di reparti di cura.

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